Fri Sep 27 2024

131 articles - From Friday Sep 20 2024 to Friday Sep 27 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol

THE LYON SCORE: A NOVEL REFLUX SCORING SYSTEM BASED ON THE LYON CONSENSUS 2.0 THAT ASSOCIATES WITH TREATMENT OUTCOME FROM ANTI-REFLUX THERAPY.

The novel Lyon score segregates reflux phenotypes, and identifies likelihood of symptom response from antireflux therapy.

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Clin Gastroenterol Hepatol

American Gastroenterological Association Clinical Practice Update on Endoscopic Scoring Systems in Inflammatory Bowel Disease: Commentary.

Methods This expert commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. Results/conclusion This expert commentary incorporates essential studies in this field and reflects the authors' expertise in the endoscopic evaluation of inflammatory bowel disease.

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Endoscopy

Diversity, equity, and inclusion in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy Position Statement.

11: ESGE identifies mentorship and sponsorship as factors that may mitigate the barriers to academic careers for underrepresented endoscopy scholars. 12: ESGE recognizes the need to increase awareness of diversity, equity, and inclusion (DEI) in the field of endoscopy and supports publications on these topics.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-analysis: Risk of lymphoma in patients with inflammatory bowel disease in population-based cohort studies.

The risk of lymphoma is only modestly increased in patients with IBD, with Crohn's disease having a slightly higher risk than ulcerative colitis. In IBD, there appears to be no difference between the risks of Hodgkin's and non-Hodgkin's lymphoma.

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Am J Gastroenterol

Comparative efficacy and safety of Potassium-Competitive Acid Blocker (P-CAB) based dual, triple and quadruple regimens for first line H. pylori infection treatment: A systematic review and network meta-analysis.

In this NWM concerning the comparative efficacy and safety of P-CAB based dual, triple and quadruple regimens for first line H. pylori infection treatment, the overall results showed that PCAB based dual treatment ranked first for efficacy with the best-integrated efficacy-safety profile. This is of importance, since the dual regimens overcome the crucial issue of clarithromycin resistance. Consequently, these findings are expected to be useful in helping clinical decision-making and future guidelines.

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Participation and Yield in Multiple Rounds of Colorectal Cancer Screening based on Fecal Immunochemical Test: A Systematic Review and Meta-Analysis.

In population-based CRC screening programs, the participation exhibited a slow upward trend for both screening strategies, but the incremental benefits in CRC detection gradually diminished. Tailored strategies, such as extending intervals for individuals with multiple negative FIT results, might optimize effectiveness and cost-efficiency in population-based CRC screening.

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TEMPORAL TREND OF INCIDENCE AND PREVALENCE OF EOSINOPHILIC ESOPHAGITIS IN ASIA: A SYSTEMATIC REVIEW AND META-ANALYSIS.

The prevalence and incidence of EoE in Asia have been rising over the past decades. Due to the limited number of Asian studies and variations in subjects' sources, caution should be exercised when interpreting these results.

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Clin Gastroenterol Hepatol

Interventions to Increase Follow-Up of Abnormal Stool-Based Colorectal Cancer Screening Tests in Safety Net Settings: A Systematic Review.

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Gastroenterology

Interventions to Increase Follow-Up of Abnormal Stool-Based Colorectal Cancer Screening Tests in Safety Net Settings: A Systematic Review.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

A nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk.

Histological inflammation in IBD predicted a small increase in short-term fracture risk. Measures to reduce disease activity may reduce fracture risk in IBD.

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Eight-year efficacy and safety of tenofovir alafenamide for treatment of chronic hepatitis B virus infection: Final results from two randomised phase 3 trials.

Long-term TAF treatment exhibited favourable safety and tolerability with high rates of viral suppression and no development of resistance. numbers NCT01940341 and NCT01940471.

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Identification of four novel acute-on-chronic liver failure clusters with distinct clinical trajectories and mortality using machine learning methods.

ML for the first time could identify clusters with distinct phenotypes, trajectories and outcomes in ACLF. Stratification into clusters can address heterogeneity, guide prognosis, recruitment in trials, resource allocation and liver transplant discussions in ACLF.

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Impact of non-selective beta blockers on further decompensation and death in decompensated cirrhosis: Benefit and risk stratification by MELD score.

NSBBs may be beneficial for the prevention of further decompensation in cirrhotic patients with a MELD score of ≤9, but deleterious in those with a MELD score of >9.

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Individualized HCC surveillance using risk stratification scores in advanced fibrosis and cirrhotic HCV patients who achieved SVR: Prospective study.

Individualized risk stratification using HCC risk scores was associated with improved early-stage detection and receipt of curative treatment.

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Insulin-like growth factor-1 in cirrhosis is linked to hepatic dysfunction and fibrogenesis and predicts liver-related mortality.

Decreased levels of IGF-1 reflect impaired hepatic function and fibrogenesis in patients with cirrhosis, which seems particularly relevant in obesity since low IGF-1 was independently linked to high BMI. Lower IGF-1 in cirrhosis predicts decompensation, ACLF and liver-related death.

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Metabolic dysfunction-associated steatotic liver disease and MetALD increases the risk of liver cancer and gastrointestinal cancer: A nationwide cohort study.

This study showed that MASLD and MetALD are associated with an increased risk of cancer, particularly liver and gastrointestinal cancers. The findings build new evidence for the clinical outcomes of MetALD while highlighting the importance of managing alcohol intake properly in MASLD and MetALD.

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The association between alcohol consumption and cardiometabolic factors and liver fibrosis in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction and alcohol-associated liver disease.

Although both metabolic steatotic liver disease and metabolic alcohol-associated liver disease were correlated with liver fibrosis progression in both sexes, the impact of alcohol consumption and cardiometabolic factors on fibrosis progression differed by sex. Cardiometabolic factors may have a stronger impact on liver fibrosis than alcohol consumption in males with metabolic dysfunction-associated steatotic liver disease.

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Time to use the right classification to predict the severity of checkpoint inhibitor-induced liver injury, as assessed for causality using the updated RUCAM.

This retrospective study challenges the efficacy of the CTCAE classification in defining the severity of Checkpoint Inhibitor-induced hepatitis and suggests that the traditional hepatology-focused scores may be more relevant. The CTCAE classification is inconsistent and gives equal weight to jaundice and elevated transaminases, which leads to steroid overtreatment and limits the rechallenge of ICIs.

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Am J Gastroenterol

A new drying method of thermolabile flexible endoscope channels by laminar and turbulent airflow - a prospective, randomized-controlled, single-center, proof-of-concept trial.

Drying with a special automatic drying device was superior compared with an EWD's drying program as evidenced by no measurable residual water, reduced microbiological contamination and a more than two-fold decrease in operational time. Thus, drying by laminar and turbulent airflow may represent an attractive alternative to the currently used standard approach in the reprocessing process of flexible endoscopes.

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Anti-Tumor Necrosis Factor Therapy and the Risk of Gestational Diabetes in Pregnant Women with Inflammatory Bowel Disease.

This nationwide cohort reported a decreased risk of GDM among patients who used anti-TNFs during early pregnancy compared to those unexposed. GDM risk may become a consideration in the decision-making process when choosing treatment options for pregnant women with a risk factor for GDM.

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COLORECTAL NEUROENDOCRINE NEOPLASM DETECTION RATE DURING COLONOSCOPY: RESULTS FROM LARGE-SCALE DATA OF COLONOSCOPIES IN JAPAN.

The detection rate of colorectal NENs during colonoscopy is substantially higher than expected.

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Evaluating Equity in Clinical Trial Accessibility: An Analysis of Demographic, Socioeconomic, and Educational Disparities in IBS Drug Trials.

The findings highlight significant disparities in IBS trial participation across race, ethnicity, gender, and socioeconomic backgrounds. This raises potential concerns about generalizability of trial outcomes and underscores the need for strategies to enhance inclusivity in clinical research.

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Global Epidemiology of Cirrhosis in Women.

Sex differences in epidemiology are likely multifactorial, influenced by varying risk factors, susceptibility and behaviors between sexes. Further research is necessary to better understand these disparities and to tailor sex-specific interventions towards improved management and treatment strategies, ultimately enhancing outcomes for women with cirrhosis and providing better patient-centered care.

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Health state utility is substantially reduced with an increasing burden of patient-reported symptoms in eosinophilic esophagitis.

EoE is associated with reduced health state utility, with symptoms most strongly predicting valuation.

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Results from a psychometric validation study: irritable bowel syndrome patients report higher symptom burden using end-of-day versus real-time assessment.

Psychometric evaluation demonstrated strong validity and reliability of the ESM-PROM for real-time GI symptom assessment in IBS. In addition, the ESM-PROM provides a precise and reliable ascertainment of individual symptom pattern and trigger interactions, without the bias of peak reporting when compared to retrospective methods. This highlights its potential as a valuable tool for personalized healthcare in monitoring disease course and treatment response in IBS patients.

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The Role of Diet in Inflammatory Bowel Disease Onset, Disease Management, and Surgical Optimization.

Further research is needed to fully elucidate how, when, and in whom diet therapies may be best applied to improve clinical and disease outcomes. The aim of this review is to summarize current research findings and serve as a tool to help facilitate patient-clinician conversations.

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Worldwide Prevalence and Description of Cyclic Vomiting Syndrome According to the Results of the Rome Foundation Global Epidemiology Study.

CVS is a relatively common disorder that has a negative impact on quality of life. It is important to raise awareness on this syndrome to avoid underdiagnosis and improve clinical practice.

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Clin Gastroenterol Hepatol

Efficacy and Safety of Upadacitinib for Perianal Fistulizing Crohn's Disease: A Post Hoc Analysis of 3 Phase 3 Trials.

Patients with fistulizing disease (primarily perianal) treated with upadacitinib achieved higher rates of resolution of drainage, closure of external openings, clinical remission, and endoscopic response vs placebo. numbers U-EXCEL (NCT03345849), U-EXCEED (NCT03345836), U-ENDURE (NCT03345823).

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Risk of recurrence in screen-versus non screen-detected colorectal cancer patients.

Disease-free survival was significantly better in screen-detected compared to non-screen-detected CRCs independent of age, gender, tumor location, stage and treatment, and was associated with an overall survival benefit.

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Endoscopy

Complete closure after colorectal endoscopic submucosal dissection with a re-openable clip with a sharp claw.

Fast and complete closure after colorectal ESD was successfully achieved using MCD.

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Exploring the incidence of dysplasia or adenocarcinoma in early onset Barrett's esophagus.

In this 25-year period, 231 patients were diagnosed with early onset BE in the Netherlands, with 17 patients progressing to dysplasia and three developing adenocarcinoma. This corresponded to incidence rates of 7.3 per 1000 person-years for dysplasia and 1.3 per 1000 person-years for adenocarcinoma.

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Intra- and Post-procedural Patient-reported Experience Measures and their Correlation with post-ERCP Adverse Events and Unplanned Healthcare Utilization.

Patient-reported symptom scores from a simple Likert-based PREM at the time of discharge from ERCP are associated with presentations for pancreatitis, perforation, and UHU within 30 days. Applying PREMs post-ERCP could potentially prevent UHU and/or facilitate earlier management and improved outcomes for patients with post-ERCP AEs.

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Randomized controlled trial of artificial intelligence diagnostic system in clinical practice to detect esophageal squamous cell carcinoma.

This study could not demonstrate an improvement in the esophageal cancer detection rate using the AI diagnostic support system for ESCC.

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The Gastroscopy RAte of Cleanliness Evaluation (GRACE) Scale: an international reliability and validation study.

the GRACE scale showed good interobserver agreement and reliability and good validity. The spread of this scale could enhance the quality and standardize the cleanliness of the mucosa assessment during UGI endoscopy, pushing endoscopists to obtain excellent visibility and reducing the risk of missing lesions.

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Gastroenterology

Detection of Gastrointestinal Bleeding with Large Language Models to Aid Quality Improvement and Appropriate Reimbursement.

An LLM-based pipeline can robustly detect overt GIB in the EHR with clinically relevant applications in detection of recurrent bleeding and appropriate reimbursement coding.

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Myosin Vb Traffics P-glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.

Collectively, these data demonstrate that Myo5b is necessary for the apical delivery of P-glycoprotein.

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Obesity facilitated colon cancer progression is mediated by increased diacylglycerol o-acyltransferases 1 and 2 (DGAT½) levels.

This is a novel mechanism of DGAT½-dependent metabolic and tumorigenic remodeling in obesity-facilitated colon cancer, providing a platform for the future development of effective treatments for colon cancer patients.

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Gastrointest Endosc

Automatic Endoscopic Gastroplasty For The Treatment of Obesity: Results from A Prospective Multicenter Study.

Our first-in-human study showed that the Endozip TM device is safe and effective in treating obesity. The weight loss led to comorbid changes and improvement in quality of life (, NCT04773795).

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LONG-TERM CLINICAL EVALUATION OF A DECADE WITH PERORAL ENDOSCOPIC MYOTOMY AT A SINGLE EUROPEAN TERTIARY CENTER.

Treatment success of POEM declines over time but remains sufficiently high in long-term perspective. Experience with the procedure improves the outcome. Gastroesophageal reflux affects almost half of patients early after POEM and decreases substantially over time together with rise in PPI-use.

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Optimal visual gaze pattern of endoscopists for improving adenoma detection during colonoscopy.

Colorectal adenoma detection was improved by correcting the endoscopist's gaze to the periphery of the screen, especially by dividing the screen into 6×6 segments.

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The Effect of Novel AI-based Cecum Recognition System on Adenoma Detection Metrics at Screening Colonoscopy Setting.

Implementation of a post hoc verification of cecal intubation using an AI-CRS significantly improved various adenoma metrics in screening colonoscopy.

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The application of endoscopic purse-string suture in refractory non-variceal gastrointestinal bleeding:a multicenter study (with video).

The endoscopic PSS is effective in treating refractory non-variceal gastrointestinal bleeding.

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Hepatology

Exchangeable copper for patients with Wilson disease at follow-up: rethinking normal ranges or changing methodology.

Our findings suggest that CuEX is a suboptimal tool for assessing copper homeostasis when used alone and should be used with caution if no additional information is available. Normal reference intervals for WD-treated patients should be redefined, as most of CuEX quantifications fell in the lower range, with no sign of overtreatment in these patients.

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Finite nucleos(t)ide-analogue therapy for functional cure in HBeAg-negative chronic hepatitis B: recent development in the paradigm shift.

Recently, a large study in patients with HBV cirrhosis showed not only higher 10-year HBsAg loss rate (15.3 vs 1.6%) but also ~50% lower 10-year hepatocellular carcinoma incidence (16.5 vs 29.5%) and 60% lower liver-related mortality/transplantation rate (6.1 vs 15.1%) after Nuc cessation, as compared with well-matched patients continuing Nuc therapy. Since novel drug development aiming for functional cure has not been satisfactory, the strategy of finite Nuc therapy in HBeAg-negative CHB seems to be the best realistic option for functional cure today.

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Harnessing ZIKV NS2A RNA for alleviating acute hepatitis and cytokine release storm by targeting translation machinery.

ZIKV NS2A dampens the production of proinflammatory cytokines and alleviates inflammatory injuries by interfering translation process as RNA molecules, which suggests that NS2A RNA is potentially used to treat numerous acute inflammatory diseases characterized by CRS.

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TIPE2 protein restrains invariant NKT activation and protects against immune-mediated hepatitis in mice.

Our findings reveal a new role of TIPE2 in the attenuation of iNKT cell-mediated hepatic injury. We propose that TIPE2 serves as an important regulator of immune homeostasis in the liver, and might be exploited for the therapeutic treatment of autoimmune liver diseases.

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The actin-binding protein drebrin disrupts NF2-LATS kinases complex assembly to facilitate liver tumorigenesis.

Our study identifies a novel DBN1-NF2-LATS axis, and pharmacological inhibition of DBN1 represents a promising alternative intervention targeting the Hippo pathway in cancer treatment.

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Viral antibody response predicts morbidity and mortality in alcohol-associated hepatitis.

Abstinence from alcohol is associated with a significant increase in serum viral and bacterial antibody response. Decreased serum antiviral antibody repertoire is predictive of decompensation of liver disease and mortality in patients with AH.

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J Hepatol

AI-Safe-C Score: Assessing Liver-Related Event Risks in Non-Cirrhotic Patients after Successful Direct-Acting Antiviral Treatment.

AI-Safe-C score is a useful tool for identifying patients without cirrhosis who are at higher risk of developing LREs. The post-SVR LSM, as integrated within the AI-Safe-C score, plays a critical role in predicting future LREs. Impact and implications The AI-Safe-C score introduces a paradigm shift in the management of non-cirrhotic patients post-DAA treatment, a cohort traditionally not included in routine surveillance protocols for LREs. By accurately identifying a subgroup at a comparably high risk of LREs, akin to those with advanced fibrosis, this predictive model facilitates a strategic reallocation of surveillance and clinical resources.

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Decreases in cT1 and liver fat content reflect treatment-induced histological improvements in MASH.

These results, from three combined drug trials, demonstrate that changes in multiparametric MRI markers of liver health (cT1 and PDFF) can predict histological response for steatohepatitis following therapeutic intervention. Impact and implications There is great interest in identifying suitable biomarkers that can be used to replace liver biopsy, or to identify those patients who would benefit from one, in both the clinical management of MASH and in drug development. We investigated the utility of two MRI-derived non-invasive tests, iron corrected T1 mapping (cT1) and liver fat content from proton density fat fraction (PDFF), to predict histological improvement in patients who had undergone experimental treatment for MASH. Using data from 150 people who participated in one of three clinical trials, we observed that a reduction in cT1 by over 80 ms and a relative reduction in PDFF of over 58% were the optimal thresholds for change that predicted resolution of steatohepatitis. PDFF as a marker of liver fat, and cT1 as a specific measure of liver disease activity, are both effective at identifying those who are likely responding to drug interventions and experiencing improvements in overall liver health. Clinical trial number(s) NCT02443116, NCT03976401, NCT03551522.

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Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: a post-hoc analysis of the PREDESCI trial.

Algorithms based only on LSM and platelet count are suboptimal to identify NSBB treatment candidates. Performing endoscopy in patients with indeterminate findings from NITs improved diagnostic performance and risk stratification. Endoscopy may be substituted by spleen stiffness for stratifying the risk in the grey zone. Impact and implications The PREDESCI trial demonstrated that non-selective beta-blockers prevent decompensation in CSPH patients. Still it is unclear whether we can select treatment candidates using non-invasive tests to assess the presence of CSPH without measuring HVPG. In the prospective cohort of patients screened during the trial, we showed that algorithms based on liver stiffness and platelet count had suboptimal performance, mainly due to a high rate of indeterminate results. Performing endoscopy in the grey zone patients allowed to significantly increase the number of patients with CSPH and improved the risk stratification for decompensation or death on long-term follow-up. These findings were validated in an independent cohort. In addition, a model using spleen stiffness instead of endoscopy showed similar diagnostic performance in the external validation cohort, suggesting that adequate risk stratification to select treatment candidates can be achieved with a fully non-invasive algorithm.

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Hepatocyte Aquaporin 8-mediated Water Transport Facilitates Bile Dilution and Prevents Gallstone Formation in Mice.

AQP8 plays a crucial role in facilitating water transport and bile dilution during hepatic bile formation, thereby mitigating gallstone formation in mice. Small-molecule intervention validated hepatocyte AQP8 as a promising drug target for gallstone therapy. Impact and implications The incidence of gallstone disease is high, and current drug treatments for gallstones are very limited, necessitating the identification of novel drug targets for developing new drugs with universal applicability. To our knowledge, this is the first study to provide direct evidence that hepatic water channel AQP8 plays a key role in bile dilution and gallstone formation. Modulation of hepatic water transport may provide a universal therapeutic strategy for al types of gallstone diseases.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Defining corticosteroid use in clinical trials.

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Review article: Recommendations for detection, assessment and management of suspected drug-induced liver injury during clinical trials in oncology patients.

This review brings together evidence-based recommendations and expert opinion to provide the first dedicated consensus for best practices in detection, assessment, and management of DILI in oncology clinical trials.

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Clin Gastroenterol Hepatol

Cold Snare Resection in the Colorectum: When to Choose it, When to Avoid it, and How to Do it.

Cold snare resection can be considered for certain lesions 11-19 mm in size and some lateral spreading lesions ≥ 20 mm. This review discusses tips and techniques to optimize cold snare resection.

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Culturally-sensitive and Inclusive IBD Care.

Heightening our patient care goals from cultural competence to cultural sensitivity allows healthcare professionals and the systems in which they practice to lead with cultural humility as they adopt a more inclusive and humble perspective when caring for patient groups with a diverse array of identities and cultures and to avoid maintaining the status quo of implicit and explicit biases that impede the delivery of quality IBD care. In this article, we will review the literature on IBD care in historically disadvantaged communities, address culturally-sensitive care, and propose a framework to incorporating cultural humility in IBD practices and research.

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Personalized (N-of-1) Clinical Trials for Inflammatory Bowel Disease: Opportunities and Challenges.

The N-of-1 trial design provides a patient-centered means of objectively determining individual response to therapy.

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Endoscopy

The battle to save the anus: a triumph of careful colonoscopy and medical history taking.

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Gut

What defines a healthy gut microbiome?

The review also highlights the resource-heavy nature of comprehensive gut health assessments, which hinders their practicality and broad application. Finally, we call for continued research and a nuanced approach to better understand the intricate and evolving concept of gut health, emphasising the need for more precise and inclusive definitions and methodologies in studying the microbiome.

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J Hepatol

Poor long-term outcome in patients with porto-sinusoidal vascular disease (PSVD: fact or disease misclassification?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Addressing Additional Limitations in the Study on Small Intestine Cancer Risk in Patients With Inflammatory Bowel Disease.

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Budesonide oral suspension: Expanding the toolkit for eosinophilic esophagitis.

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Epstein-Barr virus associated colitis with infectious mononucleosis.

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Pancreatic Eurytremiasis Mimics Pancreatic Intraductal Papillary Mucinous Neoplasm.

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Request for Clarification on Sample Size Calculation and Statistical Analysis.

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Small Bowel Microbiome Profiles in Overweight and Obese Humans.

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Clin Gastroenterol Hepatol

An Overview of the Challenging Process of Prior Authorization: Medical Necessity for a Better Way.

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Endoscopy

A case of endoscopic selective muscular dissection for calcifying fibrous tumor.

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A full-thickness defect: is closure the only way?

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A novel fluoroscopic system improves visibility of devices during endoscopic ultrasound-guided pancreatic duct drainage.

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A novel traction method using a multi-loop traction device in colorectal endoscopic submucosal dissection: Anchor traction method.

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Band-and-wire pulley traction: endoscopic submucosal dissection of a gigantic gastric polyp aided by a novel adaptive traction technique.

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Clip-to-clip hand-in-hand closure method for a large mucosal defect after colorectal endoscopic submucosal dissection.

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Diagnosis of rare tubular duplication small bowel malformation in adult woman by enteroscopy.

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Digital single-operator cholangioscope-assisted endoscopic retrograde appendicitis therapy in the management of Crohn's disease with acute appendicitis.

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Electrohydraulic lithotripsy using double-balloon enteroscopy for removal of true enterolith in a patient with unknown ileal stenosis.

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Endoscopic incision for removal of an impacted appendiceal fecalith.

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Endoscopic ultrasound-guided gallbladder drainage using a forward-viewing echoendoscope for Roux-en-Y reconstruction.

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Eosinophilic esophageal myositis: a rare cause of dysphagia.

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First-time endoscopic submucosal implantation of a wireless pacemaker device as a gastric submucosal electrical stimulator in a porcine model.

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Never say never: a novel approach to tackle a bleeding ectopic varix.

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Oxidized regenerated cellulose combined with hyperbaric oxygen therapy successfully managed delayed bleeding after peroral endoscopic myotomy for achalasia.

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Peroral pancreatoscopy without a guidewire for intraductal papillary mucinous neoplasm.

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Removal of an embedded esophageal fishbone by minimal incision using the gel immersion endoscopic ultrasound-guided technique.

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Segmental absence of intestinal musculature in the cecum of an adult identified during endoscopic submucosal dissection.

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Strange case of a suspected foreign body after cephalic pancreatoduodenectomy.

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Two colonic endoscopic submucosal dissections with a single multipolar adjustable traction device: an ecological tip to reduce waste and cost.

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Unblocking a terminolateral anastomosis on an interposed coloplasty for caustic esophagitis: placement of a lumen-apposing metal stent to straighten the lumen.

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Use of NOTES for endoscopic resection of a subphrenic mass initially diagnosed erroneously as originating from the muscularis propria.

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Use of an endoscopic virtual ruler based on the fiber laser principle and artificial intelligence technology.

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Usefulness of a small-caliber tip transparent hood in endoscopic submucosal dissection for pharyngeal cancer.

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Utility of a self-assembling peptide in the management of refractory hemorrhagic duodenal ulcers.

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Utility of endoscopic ultrasound-guided hepatic abscess drainage with contrast-enhanced harmonic imaging.

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Gastrointest Endosc

Colonic neoplasm infiltrating peritoneum and ureter: a rare case of intestinal schistosomiasis.

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Gut

Alcohol-associated hepatitis: a neutrophile disease?

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Commentary on: the management of patients with gastric intestinal metaplasia.

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High-risk varices in patients with Child-Pugh-Turcotte B and C: consider band ligation with carvedilol for preventing first variceal bleeding, especially in patients with MASLD-associated cirrhosis.

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Statins for MAFLD/MASH: another brick in the wall while waiting for final answers.

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Hepatology

Beyond the baseline: Longitudinal surveillance with non-invasive tests for fibrosis in MASLD.

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Editorial: Looking at Neptune with a binocular.

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Letter to the Editor: Benchmarking clinical risk prediction algorithms with ensemble machine learning for the non-invasive diagnosis of liver fibrosis in NAFLD.

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Letter to the Editor: Serum identification of At-Risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF).

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

GLP-1 receptor agonists: A new frontier in combating metabolic liver disease complications.

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Letter: Association of myokines with disease progression and outcomes in patients with alcohol-associated liver disease.

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Letter: Association of myokines with disease progression and outcomes in patients with alcohol-associated liver disease-Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Optimising public health policies to combat alcohol-associated liver disease in youth-Addressing key methodological and regional challenges.

Pubmed   Journal   ReadQx 

Letter: Prospective evaluation of patients with non-cirrhotic portal hypertension-A single centre study. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Prospective evaluation of patients with non-cirrhotic portal hypertension: A single-centre study.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Redefining the Curve: Insights on Baseline Viral Load and HCC Risk in Chronic Hepatitis B.

Pubmed   Journal   ReadQx 

Gastroenterology

Advancing Biofeedback Therapy in Abdominal Distention: Recommendations for Methodological Improvements and Increased Generalizability.

Pubmed   Journal   ReadQx 

Enhancing Research on Helicobacter pylori Eradication and Esophageal Adenocarcinoma Risk: A Call for Broader Studies and Methodological Rigor.

Pubmed   Journal   ReadQx 

Evaluating Research Strategy and Inclusion Criteria of Long-term Proton Pump Inhibitor Use.

Pubmed   Journal   ReadQx 

Focus on Psychological Intervention: Insights from Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention.

Pubmed   Journal   ReadQx 

Helicobacter pylori Eradication Treatment Might Help Reduce the Risk of Esophageal Adenocarcinoma.

Pubmed   Journal   ReadQx 

Interventions for improving quality of colonoscopy.

Pubmed   Journal   ReadQx 

Methodological Aspects of "Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial".

Pubmed   Journal   ReadQx 

Refining Biofeedback in Gastroenterology: Enhancing Precision in Thoracoabdominal Motion Studies.

Pubmed   Journal   ReadQx 

Gut

Rethinking routine mapping biopsies in gastric intestinal metaplasia: justification for endoscopic stratification.

Pubmed   Journal   ReadQx 

Variceal band ligation and carvedilol: together forever, or not?

Pubmed   Journal   ReadQx 

J Hepatol

A machine learning model to predict liver-related outcomes after the functional cure of chronic hepatitis B: Is cirrhosis driving the performance?

Pubmed   Journal   ReadQx 

Addressing the Complexities of Food Insecurity and MASLD: A Call for Comprehensive and Culturally Sensitive Public Health Strategies.

Pubmed   Journal   ReadQx 

Addressing the Complexities of Pre-Liver Transplant Immune Checkpoint Inhibitors for Hepatocellular Carcinoma: A Response to Recent Commentaries.

Pubmed   Journal   ReadQx 

Communicating the complexity of the transplant benefit score.

Pubmed   Journal   ReadQx 

Dysglycemia and liver lipid content influence the link between insulin resistance and liver mitochondrial function in obesity.

Pubmed   Journal   ReadQx 

Evaluating the Accuracy, Time and Cost of GPT-4 and GPT-4o in Liver Diseases Diagnoses Using Cases from "What is Your Diagnosis".

Pubmed   Journal   ReadQx 

Fatigue and Patient Reported Outcomes (PROs) in Primary Sclerosing Cholangitis.

Pubmed   Journal   ReadQx 

Harmonization of ACLF definitions- The First Step Has Gained Momentum!

Pubmed   Journal   ReadQx 

Is MASLD a real culprit for all-cause mortality? A meta-analysis and preliminary pathophysiology exploration in the real world.

Pubmed   Journal   ReadQx 

Prediction of HBsAg loss after cessation of entecavir therapy.

Pubmed   Journal   ReadQx 

Reassessing the causal association between frailty and chronic liver disease: Evidence from genetic analyses.

Pubmed   Journal   ReadQx 

Recognizing Significant Role of Microvascular Invasion in Postoperative Aggressive Recurrence of Early Hepatocellular Carcinoma.

Pubmed   Journal   ReadQx